CRISPR's unwanted anniversary
نویسندگان
چکیده
منابع مشابه
Diverse CRISPRs Evolving in Human Microbiomes
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) loci, together with cas (CRISPR-associated) genes, form the CRISPR/Cas adaptive immune system, a primary defense strategy that eubacteria and archaea mobilize against foreign nucleic acids, including phages and conjugative plasmids. Short spacer sequences separated by the repeats are derived from foreign DNA and direct interfere...
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Rapid and accurate strain identification is paramount in the battle against microbial outbreaks, and several subtyping approaches have been developed. One such method uses clustered regular interspaced short palindromic repeats (CRISPRs), DNA repeat elements that are present in approximately half of all bacteria. Though their signature function is as an adaptive immune system against invading D...
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Department of Medicine, University of Toronto, Toronto, Ontario, Canada Evaluative Clinical Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario, Canada Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Division of General Internal Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada Center for Leading Injury Prevention Practice Education & Rese...
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متن کاملHow to identify CRISPRs in sequencing data.
Clustered regularly interspaced short palindromic repeats (CRISPRs) are DNA sequences composed of a succession of repeats (23-50 bp long) separated by unique sequences called spacers. CRISPRs together with a set of genes called cas for CRISPR associated, constitute a defence mechanism against invasion by foreign sequences. We describe protocols and bioinformatics tools that allow the identifica...
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ژورنال
عنوان ژورنال: Science
سال: 2019
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.aba1751